Yu-Gi-Oh! Reshef of Destruction, known in Japan as Yu-Gi-Oh! Duel Monsters 8: Great Evil God of Destruction (遊戯王デュエルモンスターズ８ 破滅の大邪神), is a Game Boy Advance game by Konami based on the Yu-Gi-Oh! franchise.
In the start, the player is in his room with Joey. The Player, Joey, and Yugi are going to a duelist competition. Joey organizes his Deck, and asks the player how he is. The player gets two choices. Whichever he chooses doesn’t affect the plot. Joey gets excited for Duel Express tournament, but Yugi isn’t there yet and Joey gets impatient. Suddenly Yugi enters and informs them that his Millennium Puzzle has disappeared along with Yami Yugi.
Yugi and Joey then travel with the player as they leave the house. Téa is waiting at the Clock Tower Square and is shocked by the bad news, but it gets even worse. Ishizu appears, reporting that all Millennium Items have disappeared and asks the player for help in saving the world from Reshef.
To resurrect him, it is necessary to gain the power of all three Egyptian God Cards that turned into stone. To do this, the player has to locate the rest of the Millennium Items in order to revive the Egyptian Gods. The player has no choice but to start this new adventure.